In recent days the usage of many herbal formulations for various illnesses has increased. Clevira is one among them which is a polyherbal formulation consisting of many ingredients, which has antiviral activity against HSV-1 and HSV-2¹. Pre-clinical, Clinical and docking studies have also shown its antiviral activity against fever of viral origin.²

Clevira is a Proprietary Ayurvedic Medicine. The individual herbal ingredients used are known to have variety of medicinal properties against fever of viral origin and proven to have effective antipyretic, analgesic, anti-viral and immuno regulatory properties.

Composition of Clevira Tablets and Syrup as follows:

Please find below the Composition of Clevira Syrup/Tabs.

Carica papaya is known for its anti-dengue and platelet augmentation activity. It is reported to be having enhancement of arachidonate 12-lipoxygenase and the platelet activating factor receptor gene expression which is responsible for increased platelet production^{3, 4}

 Andrographis paniculata is a medicinal plant which is reported to have anti HIV, antibacterial and immune regulatory activities which also possess blood purifying activity ^{5, 6}

 Limonoids from Melia azedarach Fruits has been shown to have inhibitory activity on

Flaviviruses and Mycobacterium tuberculosis^{7, 8}

 Tinospora cordifolia which is known to strengthen host immune system by activating

macrophages, NF-kappa beta translocation and cytokine production in addition its antipyretic, antiviral and hepato-protective activity⁹

 Piper nigrum has shown to increase the bioavailability of drugs, protects the liver and neutralizes the endotoxins and detoxifies pathogenic remnants from liver and blood. Possess analgesic, anti-inflammatory, antibacterial, antifungal activities. Possesses immuno-modulatory effect which prevent the disease and facilitates reduction in signs and symptoms of patients suffering from fever of viral origin¹⁰

 Zingiber officinale is also reported to possess antipyretic, analgesic, anti-arthritic, and anti-inflammatory activities. It stimulates the secretion of gastric enzyme to recover appetite and digestion¹¹

 Cyperus rotandus possess anti-inflammatory, anti-pyretic and anti-arthritic properties.

Controls systemic inflammations and reduce fever. It also has anti-oxidant effect¹²

 Vettivera zizanoides has an effective antiviral property. Ethyl 4-(4-methylphenyl)-4 pentenoate From Vetiveria zizanioides Inhibits Dengue NS2B-NS3 Protease and Prevents Viral Assembly¹³

 Tricosanthus dioica – leaves of the plant are used as antipyretic, diuretic, cardiotonic, laxative, antiulcer, etc. The various chemical constituents present in T. dioica are vitamin

A, vitamin C, tannins, saponins, alkaloids, mixture of novel peptides, proteins tetra and pentacyclic triterpenes¹⁴

 Mollugo cerviana is commonly used to treat fever, stomach ache, jaundice, gout and rheumatism. The plant shows antimicrobial, anti-inflammatory and antioxidant activity

In excess, the plant has hepatoprotective efficiency and photo-protective capacity due to the presence of phytochemicals like carbohydrates, saponins, tannins, terpenoids, flavonoids, steroids, phenols, proteins and alkaloids ¹⁵

Indications:

As an adjuvant for increasing the thrombocytes associated with dengue fever.

Benefits:

Proven to have effective antiviral, antipyretic, analgesic, anti-inflammatory and immune regulatory properties.

Boosts immunity: Its prophylactic property helps to prevent seasonal viral fevers. Provides faster relief in conditions of viral fever in chikungunya and dengue.

Dosage: 1 tablet twice daily or 5-10 ml Syrup twice daily after food for 14 days.

Contra indications: There are no known specific contra-indications.

References:

1. 1. In vitro cytotoxicity study and Antiviral assay of Clevira. 

2. Ramesh Kannan S etal.A Randomized Open Label Parallel Group Clinical Study to Evaluatethe Efficacy and Safety of Clevira in Fever of Viral Origin. International Journal of InnovativeResearch in Medical Science (IJIRMS) Volume 04, Issue 09, September 2019.

3. Sarala N, Paknikar. Papaya extract to treat dengue: A novel therapeutic option? Annals of Medical and Health Sciences Research 2014;4:32-24.

4. Srikrishna H A, et al. Clinical Evaluation for the Thrombopoietic Activity of Platenza Tablet in Cases of Dengue with Thrombocytopenia – Randomized Open Label Comparative Clinical Study. Ann Med Health Sci Res. 2018; 8: 29-38.

5. Churiyah, Pongtuluran OB, Rofaani E, Tarwadi. Antiviral and Immunostimulant activities of Andrographispaniculata. HAYATI Journal of Biosciences April 2015;22(2):67-72.

6. Kuadkitkan A, Wikan N, Ubol S, Roytrakul S, Chu JJ, Smith DR. Activity of andrographolideagainst chikungunya virus infection. Scientific Reports 5:2015 pg 14179.

7. Sanna G, Madeddu S, Giliberti G, Ntalli NG, Cottiglia F, De Logu A, et al. (2015) Limonoids from Meliaazedarach Fruits as Inhibitors of Flaviviruses and Mycobacterium tubercolosis.PLoSONE 10(10): e0141272.

8. Alche LE, Ferek GA, Meo M, Coto CE, Maier MS. An antiviral meliacarpin from leaves of Meliaazedarach L. Naturforsch C. 2003 Mar-Apr;58(3-4):215-9.

9. Kavitha BT, Shruthi SD, Rai SP, Ramachandra YL. Phytochemical analysis and hepatoprotective properties of Tinosporacordifolia against carbon tetrachloride-induced hepatic damage in rats. Journal of Basic and Clinical Pharmacy. 2011;2:139.

10. Wadhwa S, Singhal S, Rawal S. Bioavailability enhancement by piperine: A review. Asian Journal of Biomedical and Pharmaceutical Sciences. 2014;4:1.

11. Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M. Effect of Zingiberofficinal R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med. 2012 Jul 10;12:92.

12. Al-Snafi AE. A review on CyperusrotundusA potential medicinal plant. IOSR Journal of Pharmacy. Volume 6, Issue 7 Version. 2 (July 2016), PP. 32-48.

13. Lavanya P, Ramaiah S, Anbarasu A. Ethyl 4-(4-methylphenyl)-4-pentenoate from Vetiveria zizanioides Inhibits Dengue NS2B-NS3 Protease and Prevents Viral Assembly: A Computational Molecular Dynamics and Docking Study. Cell Biochem Biophys. 2016;74(3):337-351.

14. Kumar N, Singh S, Manvi, Gupta R. Trichosanthes dioica Roxb.: An overview. Pharmacogn Rev. 2012 Jan;6(11):61-7.

15. A.A. Aglin, “Medicinal Effects of Mollugo cerviana – A Review,” International Journal of Scientific Research in Multidisciplinary Studies , Vol.4, Issue.9, pp.34-37, 2018.